Chat with us, powered by LiveChat Question: 14.You Have A Group Of Patients With Apparent Defects In Their Complement Systems. Based On The Scenarios Described Below, Provide TWO Potential Mechanisms To Explain The Patient's Defect. 10 Pts Cell-free Serum (would Contain Complement Components, If Present) Is Collected From Each Patient And Added To A Tube Containing An Encapsulated Gram Negative ... | Wridemy

Question: 14.You Have A Group Of Patients With Apparent Defects In Their Complement Systems. Based On The Scenarios Described Below, Provide TWO Potential Mechanisms To Explain The Patient’s Defect. 10 Pts Cell-free Serum (would Contain Complement Components, If Present) Is Collected From Each Patient And Added To A Tube Containing An Encapsulated Gram Negative …

14.You have a group of patients with apparent defects in their complement systems. Based on the scenarios described below, provide TWO potential mechanisms to explain the patient’s defect. 10 pts Cell-free serum (would contain complement components, if present) is collected from each patient and added to a tube containing an encapsulated Gram negative bacterium and the bacteria do not lyse. The species of bacterium used will lyse in the presence of serum from a healthy person. None of the patients are suspected to have been previously exposed to the bacterium Patient 1: Addition of IgG against the bacterium rescues lysis. Patient 2: Upon addition of macrophages, opsonophagocytoses is observed. Patient 3: Addition of cobra venom factor, a C3b protein mimic, leads to bacterial lysis only if MBP is also present. Patient 4: Addition of the patient 4 serum into a sample of normal serum prevents lysis. Patient 5: No protease activity can be detected in patient 5’s serum

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