17 Aug Question: 1) With The Following Observed Gametic Frequencies (which Are In Linkage Disequilibrium), What Is The Frequency Of The AB Gamete Type At Equilibrium? F(AB) = 0.07 F(Ab) = 0.21 F(aB) = 0.10 And F(ab) = The Remainder. Hint : The Frequency Of The AB Gamete Type At Equilibrium Is The Observed Frequency Minus The Coefficient Of Linkage Disequilibrium. So …
1) With the following observed gametic frequencies (which are in linkage disequilibrium), what is the frequency of the AB gamete type at equilibrium?
f(AB) = 0.07
f(Ab) = 0.21
f(aB) = 0.10 and
f(ab) = the remainder.
Hint : The frequency of the AB gamete type at equilibrium is the observed frequency minus the coefficient of linkage disequilibrium. So f(AB) at equilibrium = f(AB) observed – d
The correct answer should be 0.05
2) After an exhaustive and expensive process to genotype individual spermatozoa for two loci, C and D, a bleary-eyed researcher has determined that, out of 1,000 spermatozoa, the following gametes were present:
CD: 209
Cd: 307
cD: 307
and the remainder were cd.
Your job is to help the now delirious researcher to figure out if these loci are in linkage disequilibrium by calculating the coefficient of linkage disequilibrium to two decimal places.
Hint : The coefficient of linkage disequilibrium, d = ru – st where r = f(CD) = number of CD / 1,000, s = f(Cd) = number of Cd / 1,000, t = f(cD) = number of cD / 1,000 and u = f(cd) = remainder / 1,000
The correct answer should be -0.06
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