17 Aug Question: Q 1) In Practice, The Fraction Of Crossovers, C, Can Equal Zero Based On Observations With A Fixed Population Size. However, In Theory With An Infinite Population Size, We Can Never Completely Rule Out Even A Single Crossover No Matter How Close Two Loci Are To Each Other. So C Never Theoretically Equals Zero. Suppose We Have Two Loci On A Single Human …
In practice, the fraction of crossovers, c, can equal zero based on observations with a fixed population size. However, in theory with an infinite population size, we can never completely rule out even a single crossover no matter how close two loci are to each other. So c never theoretically equals zero.
Suppose we have two loci on a single human autosome. For easy calculations, assume the average chromosome in the human genome is 100 centimorgans long. A centimorgan is generally assumed to span approximately 1,000,000 bases in the human DNA sequence. Suppose we have a sufficiently large population and a single crossover event occurs between our two loci exactly in accordance with the probability that it would occur. What is the theoretical minimum number of offspring you would need to genotype in order to detect this one crossover event (assuming no genotyping errors)?
Question 15 options:
1)
100,000 random offspring
2)
1,000,000 random offspring
3)
1,000,000,000 random offspring
4)
100 random offspring
5)
100,000,000 random offspring
Q2)
If the phase of linkage disequilibrium is repulsion and the fraction of crossovers is 0.2, what will be the direction of change of the gametic frequencies after one generation of random mating if we are tracking two loci; A and B?
Question 14 options:
1)
f(AB) goes up, f(Ab) goes up, f(aB) goes down and f(ab) goes down
2)
No change
3)
f(AB) goes down, f(Ab) goes down, f(aB) goes up and f(ab) goes up
4)
f(AB) goes down, f(Ab) goes up, f(aB) goes up and f(ab) goes down
5)
f(AB) goes up, f(Ab) goes down, f(aB) goes down and f(ab) goes up
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