17 Aug Question: Activation Of Notch By Delta Binding Is Also Required To Turn On Or Maintain The Proliferation Of Some Human Stem Cells. When A Protein Binds Anything It Changes Shape Slightly. So, In Point Of Fact, Many Proteins Including All Enzymes And Receptors Have Multiple Shapes. The Difference In Shape And The Peaks And Valleys In The Folding Funnel Between …
Activation of Notch by Delta binding is also required to turn on or maintain the proliferation of some human stem cells. When a protein binds anything it changes shape slightly. So, in point of fact, many proteins including all enzymes and receptors have multiple shapes. The difference in shape and the peaks and valleys in the folding funnel between the bound and unbound conformations just aren’t very big compared to prion proteins and what we normally call inherently unstructured proteins. I have an individual whose Notch receptors have mutated in some cells to a permanently active state. The mutation changes a single residue in a turn between beta strands. Which of the following are most likely true:
Examples of folding funnels for unbound/bound conformational changes in a “structured” protein:
| A. | The patient likely will be predisposed to cancer. | |
| B. | It maybe a change in a proline or glycine. | |
| C. | Delta will bind to the modified Notch. | |
| D. | Delta will not bind to the modified Notch | |
| E. | The new shape is similar to the activated shape. | |
| F. | In the folding funnel, the valley for the new shape has become much deeper and the valley for the inactive shape has disappeared or diminished in size relative to that for the new shape. | |
| G. | In the folding funnel, the valley for the new shape has become much shallower and the valley for the inactive shape has increased in size and become deeper relative to that for the new shape. |
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